Probiotic

Lactobacillus salivarius

Lactobacillus salivarius, now classified as Ligilactobacillus salivarius, is naturally associated with the oral cavity and small intestine. It primarily ferments carbohydrates into lactic acid.

Its different preferred environment adds useful diversity to a multi-strain probiotic formulation.

In everyday life, Lactobacillus salivarius adds a complementary culture associated with the mouth and upper digestive tract, supporting a more complete digestive blend.

Probiotic benefits are strain-specific. Verified strain identity, viable CFU and storage conditions are important quality considerations.

Available in

2 products

Ingredient overview

What it is

Lactobacillus salivarius, now classified as Ligilactobacillus salivarius, is naturally associated with the oral cavity and small intestine. It primarily ferments carbohydrates into lactic acid.

  • Scientific identity: Lactobacillus salivarius; scientific identity: Ligilactobacillus salivarius.
  • How it works: Produces lactic acid: It ferments sugars homofermentatively to lactic acid; certain deposited strains also make narrow-spectrum antibacterial peptides called bacteriocins. Remains transient: It is not a permanent resident of the adult gut and is cleared over days once intake stops.
  • Primary function: Its different preferred environment adds useful diversity to a multi-strain probiotic formulation.
  • What it supports: Lactobacillus salivarius adds a complementary culture associated with the mouth and upper digestive tract, supporting a more complete digestive blend.
  • Important consideration: Effects depend on the exact bacterial strain, viable colony-forming units and appropriate storage conditions throughout shelf life.

Formulation rationale

Why we use it

CARPEDIEM selected Lactobacillus salivarius for a clearly defined role within a thoughtfully balanced formulation.

  • Formulation purpose: Its different preferred environment adds useful diversity to a multi-strain probiotic formulation.
  • Used in: CARPEDIEM HappyGut 70B Probiotic and CARPEDIEM HappyGut 140B Probiotic.
  • Works alongside: Lactobacillus salivarius complements Lactobacillus plantarum, Lactobacillus acidophilus and Bifidobacterium bifidum to support everyday digestive wellness and complementary probiotic activity.
  • Meaningful contribution: Lactobacillus salivarius adds a complementary culture associated with the mouth and upper digestive tract, supporting a more complete digestive blend. Adds an upper-digestive-tract-associated culture to a multi-strain probiotic formula.
  • Quality and scientific context: Effects depend on the exact bacterial strain, viable colony-forming units and appropriate storage conditions throughout shelf life. Research is shown only when an ingredient-specific study demonstrates a relevant benefit.

Ingredient intelligence

How it works

One of the few lactobacilli at home in both the mouth and the gut.

Step 01 / 04

Lives in two places.

Named for saliva, where it was first found, it also occurs naturally in the human small intestine.

01 / 04

Taxonomy

Ligilactobacillus salivarius

Found in

Mouth and small intestine

Fermentation

Homofermentative - lactic acid only

Extra trait

Bacteriocins - natural antibacterials

Descriptive of the ingredient's established biology. Not a claim to diagnose, treat, cure or prevent any disease.

All key functions

The complete functional profile connected with this ingredient.

Supports microbial balance through a species associated with the mouth and small intestine.

Produces lactic acid as part of its normal carbohydrate-fermentation activity.

Adds an upper-digestive-tract-associated culture to a multi-strain probiotic formula.

Complements bacterial species more commonly associated with the lower intestine.

Supports everyday digestive wellbeing through broader bacterial diversity.

Contributes a distinct ecological role within the overall probiotic formulation.

Adds a complementary culture associated with the mouth and upper digestive tract, supporting a more complete digestive blend.

Works alongside Lactobacillus plantarum and Lactobacillus acidophilus to create a more complete, complementary probiotic blend.

Selected research

Open the original paper, PubMed record or DOI page for the full publication.

01

Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study

Journal of Clinical Periodontology

A randomised, double-blind, placebo-controlled study of tablets containing Lactobacillus salivarius WB21 assessing periodontal condition in adult volunteers. L. salivarius is a species naturally resident in the mouth and upper digestive tract, and this trial characterises its behaviour at that first point of contact rather than in the lower gut.
2008
02

Probiotic effects of orally administered Lactobacillus salivarius WB21-containing tablets on periodontopathic bacteria: a double-blinded, placebo-controlled, randomized clinical trial

Journal of Clinical Periodontology

Sixty-six healthy volunteers without severe periodontitis were randomised to receive tablets delivering roughly 2 billion CFU/day of L. salivarius WB21 with xylitol, or placebo with xylitol, for eight weeks. Plaque samples were collected at baseline, week four and week eight, and bacterial quantities were measured by quantitative real-time PCR, giving an objective microbiological readout of the strain's competitive effect.
2009
03

The Probiotics in Pediatric Asthma Management (PROPAM) Study in the Primary Care Setting: A Randomized, Controlled, Double-Blind Trial with Ligilactobacillus salivarius LS01 (DSM 22775) and Bifidobacterium breve B632 (DSM 24706)

Journal of Immunology Research

A randomised, placebo-controlled, double-blind trial across 11 Italian primary care practices. A mixture of Ligilactobacillus salivarius LS01 and Bifidobacterium breve B632, each at 1 billion live cells, or placebo was taken twice daily for eight weeks and then once daily for a further eight weeks. The study examined whether strain-specific supplementation influences immune response and dysbiosis in children.
2022

Products containing Lactobacillus salivarius

Explore the Carpediem formulations connected with this ingredient.

Complementary by function

Ingredient intelligence

How it works

One of the few lactobacilli at home in both the mouth and the gut.

Step 01 / 04

Lives in two places.

Named for saliva, where it was first found, it also occurs naturally in the human small intestine.

01 04

Taxonomy

Ligilactobacillus salivarius

Found in

Mouth and small intestine

Fermentation

Homofermentative - lactic acid only

Extra trait

Bacteriocins - natural antibacterials

Descriptive of the ingredient's established biology. Not a claim to diagnose, treat, cure or prevent any disease.